GLG1 Protein

Produktnummer ABIN1589741

Dieses Recombinant GLG1-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für GLG1 Protein (ABIN1589741)

Target: GLG1 (Golgi Glycoprotein 1 (GLG1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE. Visualized by silver stain

Produktdetails

Sequenz: MTLQEAKEHR VSLKCRRQLR VEELEMTEDI RLEPDLYEAC KSDIKNFCSA VQYGNAQIIE CLKENKKQLS TRCHQKVFKL QETEMMDPEL DYTLMRVCKQ MIKRFCPEAD SKTMLQCLKQ NKNSELMDPK CKQMITKRQI TQNTDYRLNP MLRKACKADI PKFCHGILTK AKDDSELEGQ VISCLKLRYA DQRLSSDCED QIRIIIQESA LDYRLDPQLQ LHCSDEISSL CAELEHHHHH H

Produktmerkmale: Length (AA): 241

Anwendungsinformationen

Applikationshinweise: No biological data available at the moment.

Kommentare:

Soluble Receptors

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: The material is stable for greater than six months at -20° C to -70° C. After the first thawing it is recommended to aliquote the material, because repeated freeze-thaw cycles will decrease the activity.

Haltbarkeit: 6 months

Antigendetails

Target: GLG1 (Golgi Glycoprotein 1 (GLG1))

Andere Bezeichnung: ESL-1

Hintergrund: E-Selectin ligand 1/ESL 1 (GLG1, Golgi complex-Localized Glycoprotein 1, also CFR1, MG160 and Cysteine-rich FGF receptor) is a 150-160 kDa glycoprotein. The amino acid sequence of MG160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, is more than 90 % identical with CFR, a fibroblast growth factor (FGF) binding protein of chicken membranes, and with ESL-1, a ligand for E-selectin of plasma membranes of myeloid cells, furthermore, MG160, isolated by immunoaffinity chromatography from rat brain membranes, binds to basic FGF. The gene for MG160 has been assigned to human chromosome 16q22-23. The protein has a large luminal domain composed of an initial Proline-Glutamine-rich segment, encoded by an uninterrupted exonic sequence of several CAG-CAA repeats. Expansion of CAG repeats has been implicated in the etiology of several neurodegenerative diseases. The Proline-Glutamine-rich segment is followed by 16 cysteine-rich repeats that contain five potential Asparagine-linked glycosylation sites, which are conserved in the human, rat, mouse, and chicken. The large extracellular domain of the protein is followed by a single transmembrane domain and a 13-amino-acid cytoplasmic carboxy-terminal tail, which is identical to that in the chicken, rat, and mouse. It is expressed in both Golgi and/or the cell membrane of multiple cell typs, including liver stellate cells, neurons, cardiac myocytes, monocytes and bronchial epithelial cells. In the blood, GLG1/ESL-1 collaborates with PSGL-1 to mediate leukocyte binding to endothelial cell surfaces.
Synonyms: Golgi apparatus protein-1, E-selectin ligand-1, Cysteine-rich fibroblast growth factor receptor

Molekulargewicht: 28.34 kDa

NCBI Accession: NP_001139138, NM_001145666

UniProt: Q92896